Wednesday, April 8, 2020

Why pharmaceutical MNC stocks are beating their Indian peers hands down

Why pharmaceutical MNC stocks are beating their Indian peers hands down


  • Pharma MNCs are riding on innovation and are operating in niche therapies where there is less competition
  • US FDA inspections leading to cancellation of some drug launches in the US market has now impacted most Indian companies
Stocks of multinational pharmaceutical companies have outclassed their Indian peers this year, and chances are they could continue to maintain their edge in the near future. An index comprising of seven MNC pharma companies delivered returns of 9.3% since April this year as compared to a drop of 13% drop in a set of 20 Indian pharma stocks, data compiled by Mint Research shows. That results in an outperformance of as over 25%.
A combination of high domestic growth and better products in the domestic market are some of the key drivers for MNC pharma stocks.
"MNC pharma companies focus on a few brand products and enjoy premium pricing on these products as they are restricted to the top-end of the market. They also are 100% focused on the India market where there is less regulatory risk and on growing fewer premium brands in the domestic market. Whereas Indian pharmaceutical companies have about 30% of their revenue coming from the domestic market, and the rest is from overseas businesses. This exposes them to regulatory, currency and geopolitical risks which has an impact on their performance," says Krishnanath Munde, senior analyst, Reliance Securities Ltd.
No doubt, overseas exposure did boost the prospects of Indian pharmaceutical companies a few years ago, but US FDA inspections leading to cancellation of some drug launches in the US market has now impacted most Indian companies.
MNC pharma companies, on the other hand, are riding on the innovation done by their parent companies and are operating in niches and therapies where there is less competition. This gives them an edge in the domestic market. "Some MNC pharma companies are into chronic therapies, which can persist for life, which is why MNCs command a valuation premium too," notes Munde.
Besides, these companies have traditionally had negligible debt on their balance sheets and better dividend payouts.
A drawback is that many of these MNC companies are not highly liquid or heavily traded, which results in a higher impact cost for investors who want to take large positions. As their stock prices have also run up significantly, some of these stocks are beginning to quote at astronomical valuations.
Astra Zeneca, for instance, quotes at a price-earnings multiple of 74 times trailing twelve- month earnings. Correspondingly, most Indian pharma companies quote at lower than 20 times earnings on the bourses. Hence, given the run up in MNC pharma companies and some lofty valuations, a health check-up of these stocks may do no harm.

Q&A: talking drug quality with Valisure, the first analytical pharmacy

Q&A: talking drug quality with Valisure, the first analytical pharmacy
By Allie Nawrat

Grounded on personal experience of complications from taking below par drugs, Valisure is the only pharmacy in the US that puts each and every batch of medicines it buys through rigorous chemical tests before selling them to patients. Allie Nawrat talks to Valisure co-founder and CEO David Light about the company’s business model and why it has taken on the responsibility of quality assurance.



                                     CEO : DAvid Light
In September 2019, the US Food and Drug Administration (FDA) recalled generic versions of Zantac (ranitidine) after impurities of the carcinogen N-nitrosodimethylamine were found in numerous batches being distributed in the US. Other regulators quickly followed suit and began to recall all generic versions of ranitidine.
The company that first discovered the carcinogens in Zantac and reported them to the FDA was analytical pharmacy, Valisure.
This is just one high profile example, but Valisure chemically tests every batch of every medication it buys to ensure that the drugs being sold are exactly as they should be before selling them to patients.
Looking generally at Valisure’s work, CEO and co-founder David Light explains why the company’s has stepped up to guarantee safe, high quality drugs are dispensed to patients, while other industry stakeholders have largely sought to place responsibility for drug quality assurance elsewhere.

Allie Nawrat: What motivated you and your co-founder Adam Clark-Joseph to create Valisure?

David Light: Valisure started when a good friend of mine from college, Adam, called me up one day and to tell me about all these problems he was having with his anticonvulsant medication. Every once in a while he’d refill his meds and that month he felt terrible side effects and sometimes relapsed. He talked to his doctors, who said: “Listen, these days, most drugs are made in India and China, and there’s a lot of variability, and [there is] nothing we or your pharmacist can do about it”. But he obviously didn’t like that answer, so called me up. My background is in technology development of biotech tools, and I have spent a long time [working on] DNA sequencing developments.
The reality is that the only time that medications are actually chemically checked is sometimes at the manufacturing stage, which is then self-reported to the FDA. Maybe that worked better when things were done more locally, but with everything going overseas, [there are] a lot of cracks in the system. So, we figured let’s just do the analysis at the pharmacy, the end of the supply chain.
Currently we are rejecting over 10% of batches we’re analysing; this for a variety of reasons, [including] dosage, dissolution of the pills, incorrect ingredients and problems with contamination.

AN: How do you ensure carrying out these tests doesn’t make medicines more expensive for patients?

DL: We developed a variety of proprietary technologies, which we have ISO accreditation for, to address some of the most expensive components of analysing what is in a pill. It is all for high throughput analysis of high precision and the lowest possible cost.
The other important component of the business model is that unlike most pharmacies, we buy large amounts of inventory up front; we don’t buy day to day or even week to week, we try to buy six months or sometimes even a year’s worth of inventory. This has some float risk, but this allows us amortise our costs over a larger batch. Combining the cost savings from our technologies with buying large amounts of pills ahead of time, we can actually have a very low cost per pill. So when we sell medication to the patient, we can sell it at no additional cost.
We have good enough relationships with the various distributors we work with where we can actually sample the batches before we buy. So if they don’t pass [our testing], we just don’t buy them;. But if they do pass, we buy a large amount of that batch.

AN: How have regulators, patients and the pharma industry responded to Valisure’s approach?

DL: Patients have been very engaged. We’ve had a many telling us that they’ve had numerous problems with their medications and so they don’t trust them. Now we’ve created this category of the validated generic, which this has resonated a lot with patients, particularly those taking psychotropic drugs, anti-epileptic drugs, antidepressants, [as these are] areas where people really feel the differences in their medications.
What’s also been really interesting is that doctors, pharmacists and pharmacologists are proud that we’re doing this. They have known for a long time that these problems exist – there are a number of professionals, such as doctors at the Cleveland Clinic and Joe Graydon of the People’s Pharmacy, who have been outspoken critics for decades – and now they are excited that we’re actually doing something about it.
Companies that are making the drugs in much more high-quality environments and processes have reached out to us [asking] about ways we can work together as an industry to shine more light on which products are quality and which are not. Currently, the way the regulatory system works is that as long as it is an FDA approved facility, then [it is presumed] all the medicines are the same, but we see that they are definitely not. This disincentives companies that are going above and beyond for quality as those who are cutting corners on quality and using very cheap solvents are making a lot more profit.
Regulators have been very open to working with us although the legal infrastructure for building out an analytical pharmacy is entirely novel. The FDA has inspected us to ensure we are independent from pharma companies and has also requested that we just take our information, data and send it back to the industry to alert them of problems.

AN: Whose responsibility is it to ensure drugs that reach patients are of the right quality?

DL: Honestly, one of the problems [with the current system] is that [responsibility for drug quality assurance] is so shared. For the most part this has worked, most drugs that we see are of high quality; overall the pharmaceutical industry has doubled the human lifespan and created amazing products.
However, in a self-regulated industry with shared responsibility, there can be serious cracks and unfortunately it seems that these cracks are only getting bigger. Everybody agrees that there are problems in the system and they were getting worse, but nobody wants to do anything extra to help.
Manufacturers, distributors, big pharmacies all say: “It’s not our responsibility to do more quality assurance”. But at Valisure we have taken on the responsibility ourselves, [we see it as] our mission to plug [those gaps] and achieve that core value of quality assurance in terms of medications to affect as many patients as possible. We do this at the end of the supply chain before it’s actually going to get to a patient or a hospital; that’s where it’s most important to look.
But there really needs to be more vigilance and more responsibility across the supply chain and throughout the healthcare industry; supported by regulation, but [there is no need] to wait for the rules to change [before taking action on drug quality], Valisure didn’t.

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